Acute and Sub-Chronic Toxicity Study of Trichosanthes dioica Root in Mice

In the present study, the safety profile of Trichosanthes dioica root was evaluated by acute and sub-chronic toxicity study of the hydro alcoholic extract of T. dioica root (TDA) in Swiss albino mice. The oral median lethal dose (LD ) of TDA was found to be 2800 mg/kg body weight. For sub-chronic toxicity study 50 TDA was administered at the single daily dose of 10 mg/kg for 28 consecutive days; and at the 29 day, the th hematological, serum and liver biochemical parameters were evaluated. No mortality and signs and symptoms of toxicity were observed during the course of whole study period. No significant alterations were found in hematological, serum and liver biochemical parameters in TDA treated mice when compared to vehicle control group after 28 days. The results of the present study therefore indicated that T. dioica root extract may be regarded as safe in Swiss albino mice when given orally eliciting no noticeable toxicity.